Investigation of the Mechanism of Traditional Chinese Medicines in Angiogenesis through Network Pharmacology and Data Mining

Although traditional Chinese medicine is effective and safe for the treatment of angiogenesis, in vivo intervention mechanism diverse, complex, largely unknown. Therefore, we aimed to explore active ingredients their mechanisms action against angiogenesis. Data on angiogenesis-related targets were collected from GeneCards, Therapeutic Target Database, Online Mendelian Inheritance Man, DrugBank, DisGeNET. These matched related molecular compounds system pharmacology platform. The data integrated based condition degree > 1, relevant literature, target-compound, compound-medicine, target-compound-medicine networks constructed using Cytoscape. Molecular docking was used predict predominant binding combination core components. We obtained 79 angiogenesis; 41 3839 compounds, which 110 selected owing high correlation with Fifty-five combinations network by docking, among PTGS2-astragalin (?9.18 kcal/mol), KDR-astragalin (?7.94 PTGS2-quercetin (?7.41 PTGS2-myricetin (?7.21 kcal/mol) top. results indicated that potential have good activity targets. Eighty new network, top affinity KDR-beta-carotene (?10.13 MMP9-beta-sitosterol (?8.04 MMP9-astragalin (?7.82 MMP9-diosgenin (?7.51 kcal/mol). included PTGS2, KDR, VEGFA, MMP9. essential components identified astragalin, kaempferol, myricetin, quercetin, ?-sitosterol. crucial medicines Polygoni Cuspidati Rhizoma et Radix, Morus alba Root Bark, Forsythiae Fructus. By systematically analysing targets, it possible determine pathological Our study provides a basis further research development therapeutics